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anti hes1  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology anti hes1
    Anti Hes1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 418 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hes1/HES1+Antibody/pm41895783-88-23-27
    Average 95 stars, based on 418 article reviews
    anti hes1 - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Staining:

    Article Title: Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy.
    Article Snippet: .. 1 3 chloride (100 mM: Sigma) at room temperature for 10 min and they were then stained overnight with primary antibodies against Notch3 (Santa Cruz Biotechnology, Heidelberg, Germany), Notch2 (BioLegend, Barcelona, Spain), Hes1 (Santa Cruz Biotechnology, Heidelberg, Germany) and Giantin (Biolegend, Barcelona, Spain), all diluted 1:100. .. Subsequently, the coverslips were rinsed 10 times in 0,1% Tween-Tris-buffered saline (T-TBS) and incubated at room temperature for 1 h with the appropriate Alexa Fluor® 488 or Alexa Fluor® 598 conjugated IgGs (Invitrogen, Carlsbad, CA, USA).

    Article Title: Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
    Article Snippet: After washing twice with PBS, 0.1% Triton X-100 (Sigma) was added to permeabilize the fixed cells for 10 min at room temperature. .. The cells were then incubated with ammonium chloride (100 mM: Sigma) at room temperature for 10 min and they were then stained overnight with primary antibodies against Notch3 (Santa Cruz Biotechnology, Heidelberg, Germany), Notch2 (BioLegend, Barcelona, Spain), Hes1 (Santa Cruz Biotechnology, Heidelberg, Germany) and Giantin (Biolegend, Barcelona, Spain), all diluted 1:100. .. Subsequently, the coverslips were rinsed 10 times in 0,1% Tween-Tris-buffered saline (T-TBS) and incubated at room temperature for 1 h with the appropriate Alexa Fluor ® 488 or Alexa Fluor ® 598 conjugated IgGs (Invitrogen, Carlsbad, CA, USA).

    Incubation:

    Article Title: Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
    Article Snippet: After washing twice with PBS, 0.1% Triton X-100 (Sigma) was added to permeabilize the fixed cells for 10 min at room temperature. .. The cells were then incubated with ammonium chloride (100 mM: Sigma) at room temperature for 10 min and they were then stained overnight with primary antibodies against Notch3 (Santa Cruz Biotechnology, Heidelberg, Germany), Notch2 (BioLegend, Barcelona, Spain), Hes1 (Santa Cruz Biotechnology, Heidelberg, Germany) and Giantin (Biolegend, Barcelona, Spain), all diluted 1:100. .. Subsequently, the coverslips were rinsed 10 times in 0,1% Tween-Tris-buffered saline (T-TBS) and incubated at room temperature for 1 h with the appropriate Alexa Fluor ® 488 or Alexa Fluor ® 598 conjugated IgGs (Invitrogen, Carlsbad, CA, USA).

    Article Title: Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1
    Article Snippet: .. The membranes were then incubated overnight in a low-speed shaker maintained at 4°C with primary antibodies against the following: HES1 (1:500; cat. no. sc-5392; Santa Cruz Biotechnology, Inc.), PTGS2 (1:1,000; cat. no. 12375-1-AP; Proteintech Group, Inc.), GPX4 (1:800; cat. no. 381958; ZEN-BIO), P62 (1:5,000; cat. no. 18420-1-AP; Proteintech Group, Inc.), LC3B (1:800; cat. no. 381544; ZEN-BIO), NDUFB8 (1:800; cat. no. 383060; ZEN-BIO), UQCRC2 (1:800; cat. no. 382096; ZEN-BIO), Bcl-2 (1:800; cat. no. 381702; ZEN-BIO), Bax (1:800; cat. no. 380709; ZEN-BIO), phosphorylated (p-) AMPK (1:800; cat. no. 381164; ZEN-BIO), AMPKα (1:1,000; cat. no. AF6195; Beyotime Biotechnology) and β-actin (1:2,000; cat. no. 20536-1-AP; ProteinTech Group, Inc.). ..

    Article Title: BIT1 as an Effector of EGFR-TKI-induced Apoptosis via TLE1 Inhibition in Lung Adenocarcinoma Cells.
    Article Snippet: .. For transient knockdown studies, control non-targeting siRNA (cat. no.: sc-37007, Santa Cruz Biotechnology) or pool of siRNAs specifically targeting TLE1 (cat. no.: sc-38558, Santa Cruz Biotechnology) or Bit1-targeting siRNA (cat. no.: AM16708, Invitrogen), or HES1-targeting siRNAs (cat. no.: sc-37938, Santa Cruz Biotechnology) were transfected into the cells using Lipofectamine RNAiMAX transfection reagent, following manufacturer’s instructions (cat. no.: 13778100, Invitrogen) and incubated for at least 24 h followed by subsequent experimentation. ..

    Knockdown:

    Article Title: BIT1 as an Effector of EGFR-TKI-induced Apoptosis via TLE1 Inhibition in Lung Adenocarcinoma Cells.
    Article Snippet: .. For transient knockdown studies, control non-targeting siRNA (cat. no.: sc-37007, Santa Cruz Biotechnology) or pool of siRNAs specifically targeting TLE1 (cat. no.: sc-38558, Santa Cruz Biotechnology) or Bit1-targeting siRNA (cat. no.: AM16708, Invitrogen), or HES1-targeting siRNAs (cat. no.: sc-37938, Santa Cruz Biotechnology) were transfected into the cells using Lipofectamine RNAiMAX transfection reagent, following manufacturer’s instructions (cat. no.: 13778100, Invitrogen) and incubated for at least 24 h followed by subsequent experimentation. ..

    Control:

    Article Title: BIT1 as an Effector of EGFR-TKI-induced Apoptosis via TLE1 Inhibition in Lung Adenocarcinoma Cells.
    Article Snippet: .. For transient knockdown studies, control non-targeting siRNA (cat. no.: sc-37007, Santa Cruz Biotechnology) or pool of siRNAs specifically targeting TLE1 (cat. no.: sc-38558, Santa Cruz Biotechnology) or Bit1-targeting siRNA (cat. no.: AM16708, Invitrogen), or HES1-targeting siRNAs (cat. no.: sc-37938, Santa Cruz Biotechnology) were transfected into the cells using Lipofectamine RNAiMAX transfection reagent, following manufacturer’s instructions (cat. no.: 13778100, Invitrogen) and incubated for at least 24 h followed by subsequent experimentation. ..

    Transfection:

    Article Title: BIT1 as an Effector of EGFR-TKI-induced Apoptosis via TLE1 Inhibition in Lung Adenocarcinoma Cells.
    Article Snippet: .. For transient knockdown studies, control non-targeting siRNA (cat. no.: sc-37007, Santa Cruz Biotechnology) or pool of siRNAs specifically targeting TLE1 (cat. no.: sc-38558, Santa Cruz Biotechnology) or Bit1-targeting siRNA (cat. no.: AM16708, Invitrogen), or HES1-targeting siRNAs (cat. no.: sc-37938, Santa Cruz Biotechnology) were transfected into the cells using Lipofectamine RNAiMAX transfection reagent, following manufacturer’s instructions (cat. no.: 13778100, Invitrogen) and incubated for at least 24 h followed by subsequent experimentation. ..



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    Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), <t>Hes1</t> (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.
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    Image Search Results


    Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.

    Journal: Molecular Metabolism

    Article Title: Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas

    doi: 10.1016/j.molmet.2026.102362

    Figure Lengend Snippet: Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.

    Article Snippet: Real-time PCR was performed using TaqMan Gene Expression Master Mix (Applied Biosystems) and TaqMan probes for Notch1 (catalog #: Mm00627185_m1), Hes1 (catalog #: Mm00468601_m1), Ngn3 (catalog #: Mm00437606_s1), Eif5a (catalog #: Mm00839121_gH), Ins1 (catalog # Mm01259683_g1), Gcg (catalog # Mm00801714_m1), Sst (catalog # Mm00436671_m1), and Luciferase (catalog #: Mr03987587_mr).

    Techniques: Mutagenesis, Staining, Expressing, Gene Expression